LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson’s Disease through Activating α-Synuclein Expression
Joint Authors
Xu, Xiaonan
Zhuang, Chengle
Wu, Zimu
Qiu, Hongyan
Feng, Haixia
Wu, Jun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Long intergenic noncoding RNA-p21 (lincRNA-p21) has been reported to be increased in Parkinson’s disease (PD).
However, the function and underlying mechanisms of lincRNA-p21 remain not clear.
In order to explore the role of lincRNA-p21 in PD, we used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to induce in vivo PD model (C57BL/6 mice) and utilized N-methyl-4-phenylpyridinium (MPP+) to create in vitro PD model (SH-SY5Y cells).
Results showed that the expression level of lincRNA-p21 was increased significantly in PD models.
High abundance of lincRNA-p21 inhibited viability and promoted apoptosis markedly in SH-SY5Y cells treated with MPP+.
Mechanistically, further experiments demonstrated that upregulation of lincRNA-p21 could sponge miR-1277-5p and indirectly increase the expression of α-synuclein to suppress viability and activate apoptosis in SH-SY5Y cells.
In short, our study illustrated that lincRNA-p21/miR-1277-5p axis regulated viability and apoptosis in SH-SY5Y cells treated with MPP+ via targeting α-synuclein.
LincRNA-p21 might be a novel target for PD.
American Psychological Association (APA)
Xu, Xiaonan& Zhuang, Chengle& Wu, Zimu& Qiu, Hongyan& Feng, Haixia& Wu, Jun. 2018. LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson’s Disease through Activating α-Synuclein Expression. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128947
Modern Language Association (MLA)
Xu, Xiaonan…[et al.]. LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson’s Disease through Activating α-Synuclein Expression. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128947
American Medical Association (AMA)
Xu, Xiaonan& Zhuang, Chengle& Wu, Zimu& Qiu, Hongyan& Feng, Haixia& Wu, Jun. LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson’s Disease through Activating α-Synuclein Expression. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128947