RNA Sequencing Reveals the Suitability of Cardiac Death Livers for Transplantation
Joint Authors
Chen, Xinguo
Shen, Zhongyang
Zhang, Xuyi
Guo, Jing
Hao, Yuwen
Cao, Li
Yue, Yang
Wu, Fengdong
Wang, Yi
Wang, Letian
Mao, Sha
Zhang, Qing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Organ transplantation is considered the best treatment for end-stage organ failure.
However, the lack of available organs for transplantation and the increasing number of patients waiting for transplants are primary issues facing the transplant community.
Thus, developing strategies to increase the number of donors, especially for liver transplantation, has become a priority.
The use of organs acquired from donors who suffered cardiac related deaths has increased the pool of potential liver donors.
However, donation after cardiac death (DCD) livers increases the risk of primary graft dysfunction.
Methods.
In the current study, we conducted transcriptome sequencing using livers from a DCD rat to assess the short-term feasibility and functional efficacy of DCD livers.
RNA sequencing (RNAseq) data showed that the liver transcriptome varied greatly in rat livers subjected to 15 minutes of cardiac arrest.
Results.
The livers used in the current study had a significant loss of normal function before transplantation.
Functional and network analyses consistently indicated that transcription and translation processes were inhibited after approximately 15 minutes of cardiac arrest.
Moreover, the transcriptomic sequencing data provides significant insight for identifying functional genes and testing additional biological questions in DCD liver transplantation in future studies.
American Psychological Association (APA)
Chen, Xinguo& Shen, Zhongyang& Zhang, Xuyi& Guo, Jing& Hao, Yuwen& Cao, Li…[et al.]. 2018. RNA Sequencing Reveals the Suitability of Cardiac Death Livers for Transplantation. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128988
Modern Language Association (MLA)
Chen, Xinguo…[et al.]. RNA Sequencing Reveals the Suitability of Cardiac Death Livers for Transplantation. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128988
American Medical Association (AMA)
Chen, Xinguo& Shen, Zhongyang& Zhang, Xuyi& Guo, Jing& Hao, Yuwen& Cao, Li…[et al.]. RNA Sequencing Reveals the Suitability of Cardiac Death Livers for Transplantation. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128988