![](/images/graphics-bg.png)
Efficacy and Safety of Intravenous Thrombolysis in Patients with Unknown Onset Stroke: A Meta-Analysis
Joint Authors
Luan, Di
Zhang, Yuanxiang
Yang, Qian
Zhou, Zhiming
Huang, Xianjun
Zhao, Shoucai
Yuan, Lili
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objectives.
Unknown onset stroke (UOS) is usually excluded from intravenous thrombolysis concerning the unclear symptom onset time.
Attempts have been done to use thrombolytic therapy in these patients.
The current meta-analysis was done to examine the efficacy and safety of intravenous thrombolysis in UOS.
Methods.
PubMed, Web of Science, and Cochrane Library were searched for studies comparing thrombolysis with conservative therapy among UOSs.
Data of good outcome (mRS, 0-2), mortality, and intracerebral hemorrhage (ICH) and symptomatic ICH (sICH) were extracted and analyzed using the Revman 5.2 software.
Results.
In total, 8 studies with 1271 subjects (542 with thrombolysis and 729 with conservative therapy) were included in this meta-analysis.
The data showed that patients receiving thrombolysis had a higher incidence of 90-day good outcome (P=0.0005) than conservative therapy.
The comparison of discharge (P=0.89) and 90-day mortality (P=0.10) in both groups did not find any significances.
The incidences of ICH (P=0.42) and sICH (P=0.06) were relatively comparable between the two therapies.
Conclusions.
Intravenous thrombolysis is a better choice for UOS patients for its efficacy and safety.
In addition, pretreatment imaging assessment is beneficial for improving the efficacy of thrombolytic therapy.
However, it needs more supporting evidences for clinical use in the future.
American Psychological Association (APA)
Luan, Di& Zhang, Yuanxiang& Yang, Qian& Zhou, Zhiming& Huang, Xianjun& Zhao, Shoucai…[et al.]. 2019. Efficacy and Safety of Intravenous Thrombolysis in Patients with Unknown Onset Stroke: A Meta-Analysis. Behavioural Neurology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128993
Modern Language Association (MLA)
Luan, Di…[et al.]. Efficacy and Safety of Intravenous Thrombolysis in Patients with Unknown Onset Stroke: A Meta-Analysis. Behavioural Neurology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1128993
American Medical Association (AMA)
Luan, Di& Zhang, Yuanxiang& Yang, Qian& Zhou, Zhiming& Huang, Xianjun& Zhao, Shoucai…[et al.]. Efficacy and Safety of Intravenous Thrombolysis in Patients with Unknown Onset Stroke: A Meta-Analysis. Behavioural Neurology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1128993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128993