The Effect of Metformin in Experimentally Induced Animal Models of Epileptic Seizure
Joint Authors
Gebre, Abadi Kahsu
Yimer, Ebrahim M.
Surur, Awol
Wondafrash, Dawit Zewdu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Epilepsy is one of the common neurological illnesses which affects millions of individuals globally.
Although the majority of epileptic patients have a good response for the currently available antiepileptic drugs (AEDs), about 30-40% of epileptic patients are developing resistance.
In addition to low safety profiles of most of existing AEDs, there is no AED available for curative or disease-modifying actions for epilepsy so far.
Objectives.
This systematic review is intended to evaluate the effect of metformin in acute and chronic animal models of an epileptic seizure.
Methods.
We searched PubMed, SCOPUS, Sciences Direct, and grey literature in order to explore articles published in English from January 2010 to November 2018, using key terms “epilepsy,” “seizure,” “metformin,” “oral hypoglycemic agents,” and “oral antidiabetic drugs”.
The qualities of all the included articles were assessed according to the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES).
Results.
Out of six hundred fifty original articles retrieved, eleven of them fulfilled the inclusion criteria and were included for final qualitative analysis.
In these studies, metformin showed to control seizure attacks by attenuating seizure generation, delaying the onset of epilepsy, reducing hippocampal neuronal loss, and averting cognitive impairments in both acute and chronic models of an epileptic seizure.
The possible mechanisms for its antiseizure or antiepileptic action might be due to activation of AMPK, antiapoptotic, antineuroinflammatory, and antioxidant properties, which possibly modify disease progression through affecting epileptogenesis.
Conclusion.
This review revealed the benefits of metformin in alleviating symptoms of epileptic seizure and modifying different cellular and molecular changes that affect the natural history of the disease in addition to its good safety profile.
American Psychological Association (APA)
Yimer, Ebrahim M.& Surur, Awol& Wondafrash, Dawit Zewdu& Gebre, Abadi Kahsu. 2019. The Effect of Metformin in Experimentally Induced Animal Models of Epileptic Seizure. Behavioural Neurology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128999
Modern Language Association (MLA)
Yimer, Ebrahim M.…[et al.]. The Effect of Metformin in Experimentally Induced Animal Models of Epileptic Seizure. Behavioural Neurology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1128999
American Medical Association (AMA)
Yimer, Ebrahim M.& Surur, Awol& Wondafrash, Dawit Zewdu& Gebre, Abadi Kahsu. The Effect of Metformin in Experimentally Induced Animal Models of Epileptic Seizure. Behavioural Neurology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1128999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128999