Effects of DCM Leaf Extract of Gnidia glauca (Fresen)‎ on Locomotor Activity, Anxiety, and Exploration-Like Behaviors in High-Fat Diet-Induced Obese Rats

Joint Authors

Kibiti, Cromwell Mwiti
Arika, Wycliffe Makori
Njagi, Joan Murugi
Ngugi, Mathew Piero

Source

Behavioural Neurology

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-12-20

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Biology
Medicine

Abstract EN

Obesity is the main component of metabolic syndromes involving distinct etiologies that target different underlying behavioral and physiological functions within the brain structures and neuronal circuits.

An alteration in the neuronal circuitry stemming from abdominal or central obesity stimulates a cascade of changes in neurochemical signaling that directly or indirectly mediate spontaneously emitted behaviors such as locomotor activity patterns, anxiety, and exploration.

Pharmacological agents available for the treatment of neurologic disorders have been associated with limited potency and intolerable adverse effects.

These have necessitated the upsurge in the utilization of herbal prescriptions due to their affordability and easy accessibility and are firmly embedded within wider belief systems of many people.

Gnidia glauca has been used in the management of many ailments including obesity and associated symptomatic complications.

However, its upsurge in use has not been accompanied by empirical determination of these folkloric claims.

The present study, therefore, is aimed at determining the modulatory effects of dichloromethane leaf extract of Gnidia glauca on locomotor activity, exploration, and anxiety-like behaviors in high-fat diet-induced obese rats in an open-field arena.

Obesity was experimentally induced by feeding the rats with prepared high-fat diet and water ad libitum for 6 weeks.

The in vivo antiobesity effects were determined by oral administration of G.

glauca at dosage levels of 200, 250, and 300 mg/kg body weight in high-fat diet-induced obese rats from the 6th to 12th week.

Phytochemical analysis was done using gas chromatography linked to mass spectroscopy.

Results indicated that Gnidia glauca showed anxiolytic effects and significantly increased spontaneous locomotor activity and exploration-like behaviors in HFD-induced obese rats.

The plant extract also contained phytocompounds that have been associated with amelioration of the main neurodegenerative mediators, viz., inflammation and oxidative stress.

These findings provide “qualified leads” for the synthesis of new alternative therapeutic agents for the management of neurologic disorders.

However, there is a need to conduct toxicity studies of Gnidia glauca to establish its safety profiles.

American Psychological Association (APA)

Arika, Wycliffe Makori& Kibiti, Cromwell Mwiti& Njagi, Joan Murugi& Ngugi, Mathew Piero. 2019. Effects of DCM Leaf Extract of Gnidia glauca (Fresen) on Locomotor Activity, Anxiety, and Exploration-Like Behaviors in High-Fat Diet-Induced Obese Rats. Behavioural Neurology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1129012

Modern Language Association (MLA)

Arika, Wycliffe Makori…[et al.]. Effects of DCM Leaf Extract of Gnidia glauca (Fresen) on Locomotor Activity, Anxiety, and Exploration-Like Behaviors in High-Fat Diet-Induced Obese Rats. Behavioural Neurology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1129012

American Medical Association (AMA)

Arika, Wycliffe Makori& Kibiti, Cromwell Mwiti& Njagi, Joan Murugi& Ngugi, Mathew Piero. Effects of DCM Leaf Extract of Gnidia glauca (Fresen) on Locomotor Activity, Anxiety, and Exploration-Like Behaviors in High-Fat Diet-Induced Obese Rats. Behavioural Neurology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1129012

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1129012