A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls

Abstract EN

Objective.

To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls.

Setting.

Hospital emergency department.

Participants.

21 women ages 18-35 with TBI and 21 controls.

Design.

Repeated measures.

Main Measures.

Serum samples at baseline and 72 hours; immunoassays for estradiol (E2), progesterone (PRO), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and cortisol (CORT); and health history.

Results.

Women with TBI had lower E2 (p=0.042) and higher CORT (p=0.028) levels over time.

Lower Glasgow Coma Scale (GSC) and OCs were associated with lower FSH (GCS p=0.021; OCs p=0.016) and higher CORT (GCS p=0.001; OCs p=0.008).

Conclusion.

Acute TBI may suppress E2 and increase CORT in young women.

OCs appeared to independently affect CORT and FSH responses.

Future work is needed with a larger sample to characterize TBI effects on women’s endogenous hormone response to injury and OC use’s effects on post-TBI stress response and gonadal function, as well as secondary injury.