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Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis
Joint Authors
Kiss, Alexander
Yunusova, Yana
Ansari, Jamal
Ramirez, Joel
Shellikeri, Sanjana
Stanisz, Greg J.
Gillingham, Susan M.
Stuss, Donald T.
Zinman, Lorne
Black, S. E.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The goal of this study was to identify neurostructural frontal lobe correlates of cognitive and speaking rate changes in amyotrophic lateral sclerosis (ALS).
17 patients diagnosed with ALS and 12 matched controls underwent clinical, bulbar, and neuropsychological assessment and structural neuroimaging.
Neuropsychological testing was performed via a novel computerized frontal battery (ALS-CFB), based on a validated theoretical model of frontal lobe functions, and focused on testing energization, executive function, emotion processing, theory of mind, and behavioral inhibition via antisaccades.
The measure of speaking rate represented bulbar motor changes.
Neuroanatomical assessment was performed using volumetric analyses focused on frontal lobe regions, postcentral gyrus, and occipital lobes as controls.
Partial least square regressions (PLS) were used to predict behavioral (cognitive and speech rate) outcomes using volumetric measures.
The data supported the overall hypothesis that distinct behavioral changes in cognition and speaking rate in ALS were related to specific regional neurostructural brain changes.
These changes did not support a notion of a general dysexecutive syndrome in ALS.
The observed specificity of behavior-brain changes can begin to provide a framework for subtyping of ALS.
The data also support a more integrative framework for clinical assessment of frontal lobe functioning in ALS, which requires both behavioral testing and neuroimaging.
American Psychological Association (APA)
Yunusova, Yana& Ansari, Jamal& Ramirez, Joel& Shellikeri, Sanjana& Stanisz, Greg J.& Black, S. E.…[et al.]. 2019. Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis. Behavioural Neurology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1129051
Modern Language Association (MLA)
Yunusova, Yana…[et al.]. Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis. Behavioural Neurology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1129051
American Medical Association (AMA)
Yunusova, Yana& Ansari, Jamal& Ramirez, Joel& Shellikeri, Sanjana& Stanisz, Greg J.& Black, S. E.…[et al.]. Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis. Behavioural Neurology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1129051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129051