Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100onlyLDLR−− Mouse Strain
Joint Authors
Lantos, Ildikó
Endrész, Valéria
Virok, Dezső Péter
Szabó, Andrea
Mosolygó, Tímea
Burián, Katalin
Lu, Xinjie
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aims.
Hyperlipidaemia model animals have been used to elucidate the role of Chlamydia pneumoniae (Cpn) infection in atherosclerosis.
The aims of this study were to investigate the proatherogenic effect of multiple Cpn infections in ApoB100only/LDLR−/− mice which based on lipid profile can be regarded as the most suitable mouse model of human hypercholesterolemia and to compare the lesion development to that in a major atherosclerosis model ApoE−/− mice.
Methods and Results.
Aorta samples of ApoB100only/LDLR−/− mice infected three times with Cpn were subjected to morphometric analyses.
Morphometric evaluation disclosed that Cpn infections exacerbated atherosclerosis development in the aortic root and descending aorta of the mice fed with normal diet.
Viable Cpn was detected in the ascending aorta by RT-PCR.
Chlamydial 16SrRNA expression showed the presence of viable Cpn in the aorta of infected animals.
A similar rate of acceleration of atherosclerosis was observed when the infection protocol was applied in ApoB100only/LDLR−/− and in ApoE−/− mice.
Conclusion.
Similar to ApoE−/− mice, ApoB100only/LDLR−/− mice with more human-relevant serum lipoprotein composition develop increased atherosclerosis after Cpn infections; thus this mouse strain can be used as a model of infection-related atherosclerosis enhancement and can provide further evidence for the proatherogenic influence of Cpn in mice.
American Psychological Association (APA)
Lantos, Ildikó& Endrész, Valéria& Virok, Dezső Péter& Szabó, Andrea& Lu, Xinjie& Mosolygó, Tímea…[et al.]. 2018. Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100onlyLDLR−− Mouse Strain. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129070
Modern Language Association (MLA)
Lantos, Ildikó…[et al.]. Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100onlyLDLR−− Mouse Strain. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1129070
American Medical Association (AMA)
Lantos, Ildikó& Endrész, Valéria& Virok, Dezső Péter& Szabó, Andrea& Lu, Xinjie& Mosolygó, Tímea…[et al.]. Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100onlyLDLR−− Mouse Strain. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129070