Systematic Analysis of RNA Regulatory Network in Rat Brain after Ischemic Stroke
Joint Authors
Liu, Juan
Zhang, Kun-shan
Hu, Bin
Li, Si-guang
Li, Qing
Luo, Yu-ping
Wang, Yang
Deng, Zhi-Feng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Although extensive studies have identified large number of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in ischemic stroke, the RNA regulation network response to focal ischemia remains poorly understood.
In this study, we simultaneously interrogate the expression profiles of lncRNAs, miRNAs, and mRNAs changes during focal ischemia induced by transient middle cerebral artery occlusion.
A set of 1924 novel lncRNAs were identified and may involve brain injury and DNA repair as revealed by coexpression network analysis.
Furthermore, many short interspersed elements (SINE) mediated lncRNA:mRNA duplexes were identified, implying that lncRNAs mediate Staufen1-mediated mRNA decay (SMD) which may play a role during focal ischemia.
Moreover, based on the competitive endogenous RNA (ceRNA) hypothesis, a stroke regulatory ceRNA network which reveals functional lncRNA:miRNA:mRNA interactions was revealed in ischemic stroke.
In brief, this work reports a large number of novel lncRNAs responding to focal ischemia and constructs a systematic RNA regulation network which highlighted the role of ncRNAs in ischemic stroke.
American Psychological Association (APA)
Liu, Juan& Zhang, Kun-shan& Hu, Bin& Li, Si-guang& Li, Qing& Luo, Yu-ping…[et al.]. 2018. Systematic Analysis of RNA Regulatory Network in Rat Brain after Ischemic Stroke. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1129089
Modern Language Association (MLA)
Liu, Juan…[et al.]. Systematic Analysis of RNA Regulatory Network in Rat Brain after Ischemic Stroke. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1129089
American Medical Association (AMA)
Liu, Juan& Zhang, Kun-shan& Hu, Bin& Li, Si-guang& Li, Qing& Luo, Yu-ping…[et al.]. Systematic Analysis of RNA Regulatory Network in Rat Brain after Ischemic Stroke. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1129089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129089