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Effect of Astragalus Polysaccharides on Cardiac Dysfunction in dbdb Mice with Respect to Oxidant Stress
Joint Authors
Yang, Yehong
Zhang, Yu
Chen, Wei
Sun, Qilin
Ju, Jing
Chen, Wenjie
Zhao, Xuelan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Oxidant stress plays an important role in the development of diabetic cardiomyopathy.
Previously we reported that Astragalus polysaccharides (APS) rescued heart dysfunction and cardinal pathological abnormalities in diabetic mice.
In the current study, we determined whether the effect of APS on diabetic cardiomyopathy was associated with its impact on oxidant stress.
Methods.
Db/db diabetic mice were employed and administered with APS.
The hematodynamics, cardiac ultra-structure, apoptosis, and ROS formation of myocardium were assessed.
The cardiac protein expression of apoptosis target genes (Bax, Bcl-2, and caspase-3) and oxidation target genes (Gpx, SOD2, t/p-JNK, catalase, t/p-p38 MAPK, and t/p-ERK) were evaluated, respectively.
Results.
APS therapy improved hematodynamics and cardinal ultra-structure with reduced apoptosis and ROS formation in db/db hearts.
In addition, APS therapy inhibited the protein expression of apoptosis target genes (Bax, Bcl-2, and caspase-3) and regulated the protein expression of oxidation target genes (enhancing Gpx, SOD2, and catalase, while reducing t/p-JNK, t/p-ERK, and t/p-p38 MAPK) in db/db hearts.
Conclusion.
Our findings suggest that APS has benefits in diabetic cardiomyopathy, which may be partly associated with its impact on cardiac oxidant stress.
American Psychological Association (APA)
Chen, Wei& Sun, Qilin& Ju, Jing& Chen, Wenjie& Zhao, Xuelan& Zhang, Yu…[et al.]. 2018. Effect of Astragalus Polysaccharides on Cardiac Dysfunction in dbdb Mice with Respect to Oxidant Stress. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129092
Modern Language Association (MLA)
Chen, Wei…[et al.]. Effect of Astragalus Polysaccharides on Cardiac Dysfunction in dbdb Mice with Respect to Oxidant Stress. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129092
American Medical Association (AMA)
Chen, Wei& Sun, Qilin& Ju, Jing& Chen, Wenjie& Zhao, Xuelan& Zhang, Yu…[et al.]. Effect of Astragalus Polysaccharides on Cardiac Dysfunction in dbdb Mice with Respect to Oxidant Stress. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129092