Aqueous Extracts of Cordyceps kyushuensis Kob Induce Apoptosis to Exert Anticancer Activity
Joint Authors
Zhao, Xuan
Yu, Xing-hui
Zhang, Guo-ying
Zhang, Hai-ying
Liu, Wei-wei
Zhang, Chang-kai
Sun, Ying-jie
Ling, Jian-ya
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cancer has become the leading cause of mortality since 2010 in China.
Despite the remarkable advances in cancer therapy, a low survival rate is still a burden to the society.
The antineoplastic activity of aqueous extracts of Cordyceps kyushuensis Kob (AECK) was measured in this study.
Results showed that AECK can significantly inhibit the proliferation and viability of U937 and K562 when treated with different concentrations of AECK, and the IC50 values of U937 and K562 were 31.23 μg/ml and 62.5 μg/ml, respectively.
Hoechst 33258 staining showed that AECK could cause cell shrinkage, chromatin, condensation, and cytoplasmic blebbing, and DNA ladder experiment revealed the evident feature of DNA fragmentation which showed that AECK could induce cell apoptosis.
Moreover, AECK gave rise to intrinsic apoptosis through increasing the amount of Ca2+ and downregulating the expression of Bcl-2.
Meanwhile, the level of Fas death receptor was elevated which indicated that AECK could lead to exogenous apoptosis in U937.
The expressions of oncogene c-Myc and c-Fos were suppressed which manifested that AECK could negatively regulate the growth, proliferation, and tumorigenesis of U937 cells.
This research presented the primary antitumor activity of AECK which would contribute to the widely use of Cordyceps kyushuensis Kob as a functional food and medicine.
American Psychological Association (APA)
Zhao, Xuan& Yu, Xing-hui& Zhang, Guo-ying& Zhang, Hai-ying& Liu, Wei-wei& Zhang, Chang-kai…[et al.]. 2018. Aqueous Extracts of Cordyceps kyushuensis Kob Induce Apoptosis to Exert Anticancer Activity. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129138
Modern Language Association (MLA)
Zhao, Xuan…[et al.]. Aqueous Extracts of Cordyceps kyushuensis Kob Induce Apoptosis to Exert Anticancer Activity. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129138
American Medical Association (AMA)
Zhao, Xuan& Yu, Xing-hui& Zhang, Guo-ying& Zhang, Hai-ying& Liu, Wei-wei& Zhang, Chang-kai…[et al.]. Aqueous Extracts of Cordyceps kyushuensis Kob Induce Apoptosis to Exert Anticancer Activity. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129138