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Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms
Author
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Clostridium difficile (C.
difficile) is the most prevalent causative pathogen of healthcare-associated diarrhea.
Notably, over the past 10 years, the number of Clostridium difficile outbreaks has increased with the rate of morbidity and mortality.
The occurrence and spread of C.
difficile strains that are resistant to multiple antimicrobial drugs complicate prevention as well as potential treatment options.
Most C.
difficile isolates are still susceptible to metronidazole and vancomycin.
Incidences of C.
difficile resistance to other antimicrobial drugs have also been reported.
Most of the antibiotics correlated with C.
difficile infection (CDI), such as ampicillin, amoxicillin, cephalosporins, clindamycin, and fluoroquinolones, continue to be associated with the highest risk for CDI.
Still, the detailed mechanism of resistance to metronidazole or vancomycin is not clear.
Alternation in the target sites of the antibiotics is the main mechanism of erythromycin, fluoroquinolone, and rifamycin resistance in C.
difficile.
In this review, different antimicrobial agents are discussed and C.
difficile resistance patterns and their mechanism of survival are summarized.
American Psychological Association (APA)
Banawas, Saeed. 2018. Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129141
Modern Language Association (MLA)
Banawas, Saeed. Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129141
American Medical Association (AMA)
Banawas, Saeed. Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129141