Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses
Joint Authors
Yee, Jeong
Kim, Woorim
Chang, Byung Chul
Chung, Jee Eun
Lee, Kyung Eun
Gwak, Hye Sun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
This study aimed to identify the possible effects of Myc and 8q24 polymorphisms on bleeding complications in patients who maintained international normalized ratio (INR) of 2.0-3.0 with warfarin therapy after cardiac valve replacement.
Methods.
Twenty-five single nucleotide polymorphisms were analyzed, including VKORC1, CYP2C9, Myc, and 8q24.
Univariate and multivariate analyses were conducted to evaluate the associations between genetic polymorphisms and bleeding complications.
Attributable risk and the number needed to genotype (NNG) were also calculated to evaluate the potential clinical value of genotyping.
Results.
We included 142 patients, among whom 21 experienced bleeding complications.
Multivariate models showed that patients carrying the CC genotype of rs6983561 and the A allele of rs13281615 at 8q24 had 27.6- and 10.0-fold higher bleeding complications, compared with patients with the A allele and the GG genotype, respectively.
For rs6983561, the attributable risk and NNG were 96.4% and 36.8, respectively, whereas, for rs13281615, the attributable risk and NNG were 90.0% and 8.3, respectively.
Atrial fibrillation was associated with a 5.5-fold increased risk of bleeding complications.
The AUROC value was 0.761 (95% CI 0.659-0.863, p<0.001), and the Hosmer–Lemeshow test showed that the fitness of the multivariate analysis model was satisfactory (χ 2=0.846; 3 degrees of freedom; p=0.838).
Conclusions.
Bleeding complications during warfarin therapy were associated with 8q24 polymorphisms and atrial fibrillation in patients with mechanical heart valves.
American Psychological Association (APA)
Yee, Jeong& Kim, Woorim& Chang, Byung Chul& Chung, Jee Eun& Lee, Kyung Eun& Gwak, Hye Sun. 2019. Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses. Cardiovascular Therapeutics،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129155
Modern Language Association (MLA)
Yee, Jeong…[et al.]. Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses. Cardiovascular Therapeutics No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1129155
American Medical Association (AMA)
Yee, Jeong& Kim, Woorim& Chang, Byung Chul& Chung, Jee Eun& Lee, Kyung Eun& Gwak, Hye Sun. Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses. Cardiovascular Therapeutics. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129155