Endowing iPSC-Derived MSCs with Angiogenic and Keratinogenic Differentiation Potential: A Promising Cell Source for Skin Tissue Engineering
Joint Authors
Man, Yi
Chen, Miao
Lin, Weimin
Hu, Chen
Qin, Siyu
Chu, Chenyu
Xiang, Lin
Qu, Yili
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based therapy for skin regeneration.
Aiming to establish human iPSCs as a potential cell source for skin tissue engineering, we expect to obtain an epidermal-like cell line with angiogenic and keratinogenic differentiation potential via inducing iPSC-derived mesenchymal stem cells (iPSC-MSCs) with basic fibroblast growth factor (bFGF) and/or keratinocyte growth factor (KGF).
The results show that iPSC-MSCs were successfully induced with a positive FGFR/KGFR expression on the cell surface.
BFGF/KGF induction could significantly increase the expression of vascularization marker CD31 and keratinization marker CK10, respectively, while when combined together, although CD31 and CK10 were still positively expressed, their expressions were lower than that of the single induction group, suggesting that the effects of the two growth factors interfered with each other.
This cell line with angiogenic and keratinogenic differentiation potential provides a promising new source of cells for the construction of well vascularized and keratinized tissue engineered skin, furthermore establishing an effective strategy for iPSC-based therapy in skin tissue engineering.
American Psychological Association (APA)
Lin, Weimin& Chen, Miao& Hu, Chen& Qin, Siyu& Chu, Chenyu& Xiang, Lin…[et al.]. 2018. Endowing iPSC-Derived MSCs with Angiogenic and Keratinogenic Differentiation Potential: A Promising Cell Source for Skin Tissue Engineering. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129160
Modern Language Association (MLA)
Lin, Weimin…[et al.]. Endowing iPSC-Derived MSCs with Angiogenic and Keratinogenic Differentiation Potential: A Promising Cell Source for Skin Tissue Engineering. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129160
American Medical Association (AMA)
Lin, Weimin& Chen, Miao& Hu, Chen& Qin, Siyu& Chu, Chenyu& Xiang, Lin…[et al.]. Endowing iPSC-Derived MSCs with Angiogenic and Keratinogenic Differentiation Potential: A Promising Cell Source for Skin Tissue Engineering. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129160