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Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes
Joint Authors
Yu, Il Je
Gulumian, Mary
Lee, Ji Hyun
Faustman, Elaine M.
Workman, Tomomi
Jeon, KiSoo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
To investigate the effect of subacute intravenous administration AgNP (silver nanoparticles, 10 nm) and AuNP (gold nanoparticles, 12.8 nm) and AgNP/AuNP mixture to blood biochemistry, hematology, and platelet coagulation, subacute toxicity study was conducted.
Methods.
AuNP and AgNP in which their size distribution was not statistically different, mixed or separate, were injected into the caudal vein of male Sprague-Dawley rats for 4 weeks.
The rats were allowed to recover for a further 4 weeks in order to examine systemic toxicity expressed in the blood biochemistry and hematology.
The dose groups (5 males per group for the administration and 3 males for the recovery) consisted of 7 divisions, i.e., control, AgNP (with a low dose of 10 μg/kg/day and a high dose of 100 μg/kg/day), AuNP (with a low dose of 10 μg/kg/day and a high dose of 100 μg/kg/day), and mixed AgNP/AuNP (with a low dose of 10/10 μg/kg/day and a high dose of 100/100 μg/kg/day).
Results.
There were no significant dose-related changes in the hematology and blood biochemical values for the rats.
Coagulation time in terms of the active partial thromboplastin time (APTT) and prothrombin time (PT) did not show any significant changes, when compared to the control group.
Conclusion.
The subacute injection of AuNP and AgNP or their mixture did not induce any noticeable systemic toxicity.
American Psychological Association (APA)
Lee, Ji Hyun& Gulumian, Mary& Faustman, Elaine M.& Workman, Tomomi& Jeon, KiSoo& Yu, Il Je. 2018. Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129164
Modern Language Association (MLA)
Lee, Ji Hyun…[et al.]. Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129164
American Medical Association (AMA)
Lee, Ji Hyun& Gulumian, Mary& Faustman, Elaine M.& Workman, Tomomi& Jeon, KiSoo& Yu, Il Je. Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129164