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Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure
Joint Authors
Zhang, Junping
Lv, Shichao
Zhou, Huan
Jia, Qiu-jin
Zhang, Ao
Li, Hao
Zhang, Xiaonan
Xie, Yingyu
Li, Yanyang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although the mechanism of the occurrence and development of heart failure has been continuously explored in the past ten years, the mortality and readmission rate of heart failure is still very high.
Modern studies have shown that gut microbiota is associated with a variety of cardiovascular diseases, among which the study of gut microbiota and heart failure attracts particular attention.
Therefore, understanding the role of gut microbiota in the occurrence and development of heart failure will help us further understand the pathogenesis of heart failure and provide new ideas for its treatment.
This paper introduced intestinal flora and its metabolites, summarized the changes of intestinal flora in patients with heart failure, clarified that intestinal barrier damage and bacterial translocation induced inflammation and immune response aggravated heart failure, and altered intestinal microflora affected various metabolic pathways including trimethylamine/TMAO, SCFA, and Bile acid pathway leads to heart failure.
At the same time, regulating intestinal microflora through diet, probiotics, antibiotics, fecal transplantation and microbial enzyme inhibitors has grown up to be a potential treatment for many metabolic disorders.
American Psychological Association (APA)
Jia, Qiu-jin& Li, Hao& Zhou, Huan& Zhang, Xiaonan& Zhang, Ao& Xie, Yingyu…[et al.]. 2019. Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure. Cardiovascular Therapeutics،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1129171
Modern Language Association (MLA)
Jia, Qiu-jin…[et al.]. Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure. Cardiovascular Therapeutics No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1129171
American Medical Association (AMA)
Jia, Qiu-jin& Li, Hao& Zhou, Huan& Zhang, Xiaonan& Zhang, Ao& Xie, Yingyu…[et al.]. Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure. Cardiovascular Therapeutics. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1129171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129171