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Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERKSTAT3NF-κB Pathway
Joint Authors
Wang, Si-Wang
Xiao, Huimin
Zhao, Rong
He, Yue
Liu, Yang
He, Qiaoyan
Chen, Fei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Coxsackievirus 16 (CA16) causes hand, foot, and mouth disease (HFMD) in young children and infants, and it can lead to fatal neurological complications.
This study investigated antiviral effects of Siji Antiviral Mixture (SAM) on CA16 in neonatal mice and the protective effects of SAM on CA16 induced brain injuries.
Neonatal BALB/c mice and SH-SY5Y cells were used and injected with CA16 stains to study the efficacy.
ELISA and Western blotting were used to measure the cytokines levels and proteins expression.
Genes transduction was also used to verify interaction mechanism.
As the results shown, SAM could reduce the clinical scores at the beginning and delay disease development in vivo.
Treatment with SAM decreased the levels of LDH, CK-MB, caspase 3 and Bax, ER stress, and inflammatory reaction induced by CA16 infection.
Further siRNA transfection results showed that CA16 induced ER stress and inflammatory reaction through PERK/STAT3/NF-κB signaling and the protective effects of SAM might be through inhibiting PERK/STAT3/NF-κB signaling.
HPLC analysis showed fingerprint profiles of SAM had 42 chromatographic peaks.
Collectively, our study highlighted distinct roles of SAM in inhibiting CA16 infection and brain injury.
The molecular mechanism of SAM might be through inhibiting PERK/STAT3/NF-κB signaling.
American Psychological Association (APA)
Xiao, Huimin& Zhao, Rong& He, Yue& Liu, Yang& He, Qiaoyan& Wang, Si-Wang…[et al.]. 2018. Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERKSTAT3NF-κB Pathway. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129174
Modern Language Association (MLA)
Xiao, Huimin…[et al.]. Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERKSTAT3NF-κB Pathway. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1129174
American Medical Association (AMA)
Xiao, Huimin& Zhao, Rong& He, Yue& Liu, Yang& He, Qiaoyan& Wang, Si-Wang…[et al.]. Siji Antiviral Mixture Protects against CA16 Induced Brain Injury through Inhibiting PERKSTAT3NF-κB Pathway. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129174