Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice
Joint Authors
Ye, Qing
Wang, Chenyi
Ren, Xiumei
You, Qing-sheng
Gu, Ming-Ming
Wang, Fei
Wang, Shuo
Ma, Chun-Hui
Li, Wei-Nan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease in China.
In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice.
Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) in serum were detected by commercial kits.
Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined.
In addition, the protein levels of the NF-кB pathway were detected to reveal its mechanism.
The results showed that DBD significantly decreased the levels of ALT, AST, CK, and LDH and increased WBCs in CTX-induced mice.
In addition, DBD significantly alleviated pathological changes of heart tissue.
DBD significantly reduced the protein expressions of NF-кB signaling pathway.
In summary, DBD can be considered an effective drug to alleviate CTX-induced heart damage in mice.
American Psychological Association (APA)
Wang, Chenyi& Ren, Xiumei& You, Qing-sheng& Gu, Ming-Ming& Wang, Fei& Wang, Shuo…[et al.]. 2018. Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129198
Modern Language Association (MLA)
Wang, Chenyi…[et al.]. Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129198
American Medical Association (AMA)
Wang, Chenyi& Ren, Xiumei& You, Qing-sheng& Gu, Ming-Ming& Wang, Fei& Wang, Shuo…[et al.]. Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129198