Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
Joint Authors
Liu, Ying
Wu, Chao
Lv, Huiling
Liu, Xuan
Bai, Andi
Cao, Yue
Shang, Wenjing
Hu, Lili
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy.
According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure.
The average outer diameter was 200 nm, and the wall thickness was 50 nm.
The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state.
The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX.
Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells.
Therefore, SFNF is a promising targeting antitumor drug delivery carrier.
American Psychological Association (APA)
Lv, Huiling& Wu, Chao& Liu, Xuan& Bai, Andi& Cao, Yue& Shang, Wenjing…[et al.]. 2018. Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129213
Modern Language Association (MLA)
Lv, Huiling…[et al.]. Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129213
American Medical Association (AMA)
Lv, Huiling& Wu, Chao& Liu, Xuan& Bai, Andi& Cao, Yue& Shang, Wenjing…[et al.]. Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129213