Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect
Joint Authors
Casquero-Veiga, Marta
García-García, David
Desco, Manuel
Soto-Montenegro, María Luisa
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Deep brain stimulation (DBS) is a neurosurgery technique widely used in movement disorders, although its mechanism of action remains unclear.
In fact, apart from the stimulation itself, the mechanical insertion of the electrode may play a crucial role.
Here we aimed to distinguish between the insertional and the DBS effects on brain glucose metabolism.
To this end, electrodes were implanted targeting the medial prefrontal cortex in five adult male Wistar rats.
Positron Emission Tomography (PET) studies were performed before surgery (D0) and seven (D7) and nine days (D9) after that.
DBS was applied during the 18FDG uptake of the D9 study.
PET data were analysed with statistical parametric mapping.
We found an electrode insertional effect in cortical areas, while DBS resulted in a more widespread metabolic pattern.
The consequences of simultaneous electrode and DBS factors revealed a combination of both effects.
Therefore, the insertion metabolic effects differed from the stimulation ones, which should be considered when assessing DBS protocols.
American Psychological Association (APA)
Casquero-Veiga, Marta& García-García, David& Desco, Manuel& Soto-Montenegro, María Luisa. 2018. Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129227
Modern Language Association (MLA)
Casquero-Veiga, Marta…[et al.]. Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1129227
American Medical Association (AMA)
Casquero-Veiga, Marta& García-García, David& Desco, Manuel& Soto-Montenegro, María Luisa. Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129227