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Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications
Joint Authors
Zhong, Jianqiao
Yang, Lingyu
Xian, Dehai
Xiong, Xia
Lai, Rui
Song, Jing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts.
Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity.
Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues.
OS is implicated in the pathogenesis and exacerbation of many cardiovascular, neurodegenerative, dermatological, and metabolic diseases, both through direct molecular damage and secondary activation of stress-associated signaling pathways.
PCs are promising natural agents to safely prevent acute damage and control chronic diseases at relatively low cost.
In this review, we summarize the molecules and signaling pathways involved in OS and the corresponding therapeutic mechanisms of PCs.
American Psychological Association (APA)
Yang, Lingyu& Xian, Dehai& Xiong, Xia& Lai, Rui& Song, Jing& Zhong, Jianqiao. 2018. Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129235
Modern Language Association (MLA)
Yang, Lingyu…[et al.]. Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129235
American Medical Association (AMA)
Yang, Lingyu& Xian, Dehai& Xiong, Xia& Lai, Rui& Song, Jing& Zhong, Jianqiao. Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129235