Effect of Repeated Remote Ischemic Preconditioning on Peripheral Arterial Disease in Patients Suffering from Intermittent Claudication
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/Objective.
Intermittent claudication (IC) is the symptom of peripheral artery disease (PAD) and causes functional disability.
Remote ischemic preconditioning (RIPC), is a phenomenon in which a short period of sub-critical ischemia, protects tissues against ischemia/reperfusion/injury.
We considered to test the hypothesis that RIPC in PAD patients suffering from IC would increase muscle resistance to ischemia and thus improve walking-capacity.
Materials/Methods.
A total of 63 patients with proven-IC underwent two treadmill tests (graded treadmill protocol) with a 28-day interval in between.
Patients were consecutively assigned for the non/RIPC-group and RIPC-group procedure one by one.
Patients received 5-cycles of alternating 5-minute inflation and 5-minute deflation of blood-pressure cuffs on nondominant upper-limb every day for four weeks.
Initial claudication distance (ICD), total walking distance (TWD) and time to relief of claudication (TRC) were recorded during procedure.
Results.
Patients receiving-RIPC exhibited a marked increase in ICD and TWD between basal and last tests: 209.1 ± 15.4 m vs.
226 ± 15.0 m and 368.8 ± 21.0 m vs.
394 ± 19.9 m, respectively ( p<0.001).
In addition, patients receiving-RIPC represented a significant decrease in TRC between basal and last tests: 7.8 ± 1.3 min vs.
6.4 ± 1.1 min, respectively ( p<0.001).
Patients not receiving-RIPC did not exhibit improvement in ICD, TWD, and TRC between basal and last tests: 205.2 ± 12.1 min vs.
207.4 ± 9.9 min, 366.5 ± 24.2 min vs.
369.4 ± 23.2 min and 7.9 ± 1.4 min vs.
7.7 ± 1.3 min, respectively ( p>0.05).
Conclusion.
A significant increase in ICD and TWD were observed in last/treadmill test in RIPC-group.
In addition, a significant decrease in TRC was observed in last/treadmill test in RIPC-group.
In non/RIPC-group, no improvement was observed in ICD, TWD and TRC.
American Psychological Association (APA)
Balin, Mehmet& Kivrak, Tarik. 2019. Effect of Repeated Remote Ischemic Preconditioning on Peripheral Arterial Disease in Patients Suffering from Intermittent Claudication. Cardiovascular Therapeutics،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1129251
Modern Language Association (MLA)
Balin, Mehmet& Kivrak, Tarik. Effect of Repeated Remote Ischemic Preconditioning on Peripheral Arterial Disease in Patients Suffering from Intermittent Claudication. Cardiovascular Therapeutics No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1129251
American Medical Association (AMA)
Balin, Mehmet& Kivrak, Tarik. Effect of Repeated Remote Ischemic Preconditioning on Peripheral Arterial Disease in Patients Suffering from Intermittent Claudication. Cardiovascular Therapeutics. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1129251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129251