Predictors of Inappropriate Proton Pump Inhibitors Use in Elderly Patients
Joint Authors
Voukelatou, Panagiota
Kalliakmanis, Andreas
Emmanouilidou, Georgia
Dodos, Konstantinos
Skotsimara, Georgia
Kontogeorgou, Dimitra
Vrettos, Ioannis
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Overutilization of Proton Pump Inhibitors (PPIs) both in ambulatory care and in the inpatient setting possesses economic implications and increases the risk for adverse drug reactions.
This study was undertaken to identify factors associated with inappropriate PPI use among consecutively unplanned admissions of elderly patients at the time of admission.
Materials and Methods.
In 758 patients (54.2% women), mean age 80.3±8.0 (M±1SD), demographic characteristics, and medical and medication history were recorded.
Parametric tests and multiple logistic regression analysis were applied to identify the predictors of inappropriate PPI use.
Results.
232 patients (30.6%) were receiving PPIs.
37 (4.9%) were receiving PPIs appropriately and 195 (25.7%) were receiving PPIs without a proper indication.
Consequently, PPIs prescribing was inappropriate in 195/232 (84%).
Moreover, 512 patients (67.5%) were not receiving PPIs appropriately and 14 patients (1.8%) were not receiving PPIs but they had a proper indication.
When we compared patients receiving PPIs without a proper indication with those who were not receiving PPIs, a statistical difference was found according to Charlson Comorbidity Index (p≤0.001, U=37922.00), number of diseases (p≤0.001, U=33269.00) and medications (p≤0.001, U=31218.50), Katz Index score (p=0.01, U=45328.00), and the use of blood thinners (p≤0.001, χ2=21.15).
In multivariate analysis the only independent predictor of inappropriate PPI use was the number of medications (p=0.001, OR=1.16, 95%CI 1.06-1.27).
Conclusions.
The main predictor of inappropriate PPI use was the number of received medications.
Εfforts needed to apply the predefined criteria for PPI prescription and to deprescribe PPIs received inappropriately.
American Psychological Association (APA)
Voukelatou, Panagiota& Vrettos, Ioannis& Emmanouilidou, Georgia& Dodos, Konstantinos& Skotsimara, Georgia& Kontogeorgou, Dimitra…[et al.]. 2019. Predictors of Inappropriate Proton Pump Inhibitors Use in Elderly Patients. Current Gerontology and Geriatrics Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1129272
Modern Language Association (MLA)
Voukelatou, Panagiota…[et al.]. Predictors of Inappropriate Proton Pump Inhibitors Use in Elderly Patients. Current Gerontology and Geriatrics Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1129272
American Medical Association (AMA)
Voukelatou, Panagiota& Vrettos, Ioannis& Emmanouilidou, Georgia& Dodos, Konstantinos& Skotsimara, Georgia& Kontogeorgou, Dimitra…[et al.]. Predictors of Inappropriate Proton Pump Inhibitors Use in Elderly Patients. Current Gerontology and Geriatrics Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1129272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129272