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Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound
Joint Authors
Rauf, Abdur
Abu-Izneid, Tareq
Patel, Seema
Bawazeer, Saud
Wadood, Abdul
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance.
The chemical structure of compound 7 (methyl 3-O-phospo-α-D-glucopyranuronic acid was elucidated by physical and advance spectral technique.
Also, this compound was assessed for various in vitro biological screening.
The results showed that compound 7 has promising antifungal activity against selected fungal strains.
Computational study was also carried out to find antimalarial efficacy of the synthesized compounds.
Compounds (2-7) were tested for cytotoxicity by MTT assay, and no considerable cytotoxicity was observed.
Molecular docking study was performed to predict the binding modes of new compound (7).
The docking results revealed that the compound has strong attraction towards the target protein, as characterized by good bonding networks.
On the basis of the acquired results, it can be predicted that compound (7) might show good inhibitory activity against dengue envelope protein.
American Psychological Association (APA)
Abu-Izneid, Tareq& Rauf, Abdur& Bawazeer, Saud& Wadood, Abdul& Patel, Seema. 2018. Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1129279
Modern Language Association (MLA)
Abu-Izneid, Tareq…[et al.]. Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1129279
American Medical Association (AMA)
Abu-Izneid, Tareq& Rauf, Abdur& Bawazeer, Saud& Wadood, Abdul& Patel, Seema. Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1129279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129279