Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis
Joint Authors
Zhou, Shuai
Sun, Chengjia
Huang, Shaohui
Wu, Ximing
Zhao, Yan
Pan, Chunling
Wang, Hongyan
Liu, Junchao
Li, Qian
Kou, Yurong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objectives.
Lots of bioactive materials have been additionally applied for the treatment of periodontal intrabony defect.
However, there is dearth of studies to systematically evaluate the supplementary role of them in periodontal regeneration.
The goal of this meta-analysis is to evaluate the adjunctive effects of bioactive materials such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), enamel matrix derivative (EMD), and amnion membrane (AM) on the outcomes of bone grafting treatment for periodontal intrabony defects.
Methods.
Articles published before December 2017 were searched electronically in three databases (PubMed, Embase, and Cochrane Central), with no date or language limits.
Randomized controlled trials (RCTs) on the assessment of effectiveness of the four biomaterials in conjunction with demineralized freeze-dried bone allografts (DFDBA) in the treatment of periodontal intrabony defects were enrolled in this meta-analysis.
Data were analyzed with STATA 12.
Results.
Nine studies were included.
PRF and PRP significantly improved pocket depth (PD) reduction and clinical attachment loss (CAL) gain.
Only PRF exhibited a positive result in recession reduction (RecRed).
Only PRP showed a statistically significant increase in bone fill.
AM merely gained more CAL.
EMD did not improve any clinical outcome.
Conclusion.
Our data suggest that PRF/PRP could be taken as a preferred adjunct to facilitate periodontal regeneration of intrabony defects.
American Psychological Association (APA)
Zhou, Shuai& Sun, Chengjia& Huang, Shaohui& Wu, Ximing& Zhao, Yan& Pan, Chunling…[et al.]. 2018. Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129282
Modern Language Association (MLA)
Zhou, Shuai…[et al.]. Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1129282
American Medical Association (AMA)
Zhou, Shuai& Sun, Chengjia& Huang, Shaohui& Wu, Ximing& Zhao, Yan& Pan, Chunling…[et al.]. Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129282