The Diverse Mechanisms of miRNAs and lncRNAs in the Maintenance of Liver Cancer Stem Cells
Joint Authors
Qin, Lun-Xiu
Wu, Jing
Zhao, Jing
Fu, Yan
Li, Juan
Huang, Guangjian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Liver cancer is the second leading cause of cancer-related death worldwide.
The high frequency of recurrence and metastasis is the main reason for poor prognosis.
Liver cancer stem cells (CSCs) have unlimited self-renewal, differentiation, and tumor-regenerating capacities.
The maintenance of CSCs may account for the refractory features of liver cancer.
Despite extensive investigations, the underlying regulatory mechanisms of liver CSCs remain elusive.
miRNA and lncRNA, two major classes of the ncRNA family, can exert important roles in various biological processes, and their diverse regulatory mechanisms in CSC maintenance have acquired increasing attention.
However, to the best of our knowledge, there is a lack of reviews summarizing these findings.
Therefore, we systematically recapitulated the latest studies on miRNAs and lncRNAs in sustaining liver CSCs.
Moreover, we highlighted the potential clinical application of these dysregulated ncRNAs as novel diagnostic and prognostic biomarkers and therapeutic targets.
This review not only sheds new light to fully understand liver CSCs but also provides valuable clues on targeting ncRNAs to block or eradicate CSCs in cancer treatment.
American Psychological Association (APA)
Zhao, Jing& Fu, Yan& Wu, Jing& Li, Juan& Huang, Guangjian& Qin, Lun-Xiu. 2018. The Diverse Mechanisms of miRNAs and lncRNAs in the Maintenance of Liver Cancer Stem Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129287
Modern Language Association (MLA)
Zhao, Jing…[et al.]. The Diverse Mechanisms of miRNAs and lncRNAs in the Maintenance of Liver Cancer Stem Cells. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129287
American Medical Association (AMA)
Zhao, Jing& Fu, Yan& Wu, Jing& Li, Juan& Huang, Guangjian& Qin, Lun-Xiu. The Diverse Mechanisms of miRNAs and lncRNAs in the Maintenance of Liver Cancer Stem Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129287