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Association of IGF-1 CA(n) and IGFBP3 rs2854746 Polymorphisms with Endometrial Polyp Risk
Joint Authors
Doria, Pedro Leopoldo Silva
Moscovitz, Thomas
Tcherniakovsky, Marcos
Fernandes, Cesar Eduardo
Pompei, Luciano Melo
Wajman, Milton
Nimwegen, Angela Van
Haimovich, Sergio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Insulin-like growth factor 1 (IGF-1) is a peptide growth factor that promotes cell proliferation and inhibits apoptosis.
The bioavailability of IGF-1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3).
Genetic variations influence the levels of IGF-1 and IGFBP3.
The purpose of this study was to examine the association of polymorphisms IGF-1 CA(n) and IGFBP3 rs2854746 with risk of endometrial polyps.
Materials and Methods.
Case control observational study, composed of 104 women with antecedent of endometrial polyp (case group) and 81 postmenopausal women without antecedent of endometrial diseases (control group).
Genotyping of IGF-1 CA(n) was performed by PCR and fragment analysis by capillary electrophoresis, and genotyping of IGFBP3 rs2854746 was performed by PCR-HRM.
Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression.
Results.
The genotype IGF-1 CA(19)/CA(19) was associated with an increased endometrial polyp risk (OR=2,57; IC 95%= 1,09 - 6,01); this was also found when combining it with CA(>19)/CA(n) genotypes (OR=2,18; IC 95%= 1,06-4,47).
The IGFBP3 rs2854746 analyses showed the CG genotype having a protective effect for endometrial polyp (OR=0,37; IC 95%= 0,19-0,73), fact also observed when grouping CG and GG carriers (OR=0,51; IC 95%= 0,28-0,93).
Conclusion.
The genotypes CA(19)/CA(19) and CA(19)/CA(19) + CA(>19)/CA(n) of the IGF-1 CA(n) may be considered a risk for endometrial polyp, whereas the genotypes CG and CG + GG of IGFBP3 rs2854746 polymorphism have an inverse effect of endometrial polyp risk.
American Psychological Association (APA)
Doria, Pedro Leopoldo Silva& Moscovitz, Thomas& Tcherniakovsky, Marcos& Fernandes, Cesar Eduardo& Pompei, Luciano Melo& Wajman, Milton…[et al.]. 2018. Association of IGF-1 CA(n) and IGFBP3 rs2854746 Polymorphisms with Endometrial Polyp Risk. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129303
Modern Language Association (MLA)
Doria, Pedro Leopoldo Silva…[et al.]. Association of IGF-1 CA(n) and IGFBP3 rs2854746 Polymorphisms with Endometrial Polyp Risk. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1129303
American Medical Association (AMA)
Doria, Pedro Leopoldo Silva& Moscovitz, Thomas& Tcherniakovsky, Marcos& Fernandes, Cesar Eduardo& Pompei, Luciano Melo& Wajman, Milton…[et al.]. Association of IGF-1 CA(n) and IGFBP3 rs2854746 Polymorphisms with Endometrial Polyp Risk. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129303