Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model
Joint Authors
Qian, Kun
Feng, Li
Sun, Yujie
Xiong, Bowen
Ding, Yi
Han, Panting
Chen, Hailun
Chen, Xiao
Du, Ling
Wang, Yuxue
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inhibiting vascular endothelial foam is the focus of clinical attention.
Using SonoVue (an ultrasound contrast agent), the salusin-α gene was transfected into the arterial intima of an atherosclerotic rabbit model induced by a high-fat diet in this study.
Subsequently the model of blood lipid indexes, the pathological structure of the intima, and changes in molecules regulating atherosclerosis were investigated.
The high-density lipoprotein C and apolipoprotein A values in the salusin-α gene overexpression (P) group were higher than those in the salusin-α gene interference (RP) group (P < 0.05), whereas the total cholesterol, low-density lipoprotein C, and apolipoprotein B values were reversed.
Rabbits in the P group showed significantly thinner vascular intimal thickness than that of other experimental groups (P < 0.05).
The expression of positive regulators of atherosclerosis (ABCA1, ABCG1) was higher in the P group than that in the RP group (P < 0.05), and the opposite effect was observed for negative regulators (ACAT1, CD36).
Thus, our results showed that the overexpression of salusin-α gene inhibited the proliferation of the vascular intima, thereby throwing some light on understanding the mechanism how salusin-α gene expression interfered with the foaming of vascular intimal cells.
American Psychological Association (APA)
Qian, Kun& Feng, Li& Sun, Yujie& Xiong, Bowen& Ding, Yi& Han, Panting…[et al.]. 2018. Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129416
Modern Language Association (MLA)
Qian, Kun…[et al.]. Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129416
American Medical Association (AMA)
Qian, Kun& Feng, Li& Sun, Yujie& Xiong, Bowen& Ding, Yi& Han, Panting…[et al.]. Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129416