Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?
Joint Authors
Likus, Wirginia
Dorecka, Mariola
Markowski, Jarosław
Siemianowicz, Krzysztof
Wilk, Renata
Dziubdziela, Włodzimierz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Head and neck squamous cell cancer (HNSCC) represents a significant burden worldwide.
Chemoprevention of HNSCC is a means of cancer control with a use of drugs or natural agents in order to hinder or delay the cancer development.
The purpose of this article is to review mechanism of action of different chemopreventive agents’ groups and results of most important researches concerning them.
The safety issues of HNSCC chemoprevention are also discussed.
In case of HNSCC there is currently no agent, which would give positive result in the third phase of clinical trials.
Promising results of preclinical trials are not always confirmed by further tests.
Main problems are low effectiveness, high toxicity, and lack of highly specificity biomarkers for monitoring the research.
New trials concerning many agents, as well as novel technologies for provision of pharmaceutical forms of them, including drug nanocarriers, are currently underway, which gives hope for finding the perfect chemopreventive agent formula.
American Psychological Association (APA)
Siemianowicz, Krzysztof& Likus, Wirginia& Dorecka, Mariola& Wilk, Renata& Dziubdziela, Włodzimierz& Markowski, Jarosław. 2018. Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129453
Modern Language Association (MLA)
Siemianowicz, Krzysztof…[et al.]. Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1129453
American Medical Association (AMA)
Siemianowicz, Krzysztof& Likus, Wirginia& Dorecka, Mariola& Wilk, Renata& Dziubdziela, Włodzimierz& Markowski, Jarosław. Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129453