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Radiotherapy for Adult Medulloblastoma: Evaluation of Helical Tomotherapy, Volumetric Intensity Modulated Arc Therapy, and Three-Dimensional Conformal Radiotherapy and the Results of Helical Tomotherapy Therapy
Joint Authors
Chen, Ming
Li, Qing-lin
Zong-wen, Sun
Shuang-yan, Yang
Feng-lei, Du
Xiao-long, Cheng
Meng-yuan, Chen
Yong-hong, Hua
Ting, Jin
Qiao-ying, Hu
Xiao-zhong, Chen
Yuan-yuan, Chen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
All adult medulloblastoma (AMB) patients should be treated with craniospinal irradiation (CSI) postoperatively.
Because of the long irradiation range, multiple radiation fields must be designed for conventional radiotherapy technology.
CSI can be completed in only one session with helical tomotherapy (HT).
We evaluated the dose of HT, volumetric intensity modulated arc therapy (VMAT), and three-dimensional conformal radiotherapy (3D-CRT) of AMB and the results of 5 cases of AMB treated with HT.
Methods.
Complete craniospinal and posterior cranial fossa irradiation with HT, VMAT, and 3D-CRT and dose evaluation were performed.
And results of 5 cases of AMB treated with HT were evaluated.
Results.
A large volume of tissue was exposed to low dose radiation in the organs at risk (OAR), while a small volume was exposed to high dose radiation with HT.
The conformity and uniformity of the targets were good with HT and VMAT, and the volume of targets exposed to high dose with VMAT was larger than that of HT.
The uniformity of 3D-CRT was also good, but the dose conformity was poor.
The main toxicity was hematologic toxicity, without 4th-degree bone marrow suppression.
There was 3rd-degree inhibition in the white blood cells, hemoglobin, and platelets.
The three female patients suffered menstrual disorders during the course of radiation.
Two female patients with heavy menstruation suffered 3rd-degree anemia inhibition, and 2 patients suffered amenorrhea after radiotherapy.
Although menstrual cycle was normal, the third patient was not pregnant.
Conclusion.
CSI with HT is convenient for clinical practice, and the side effects are mild.
With good conformity and uniformity, VMAT can also be used for selection in CSI.
For poor conformity, 3D-CRT should not be the priority selection for CSI.
In female patients, the ovaries should be protected.
American Psychological Association (APA)
Zong-wen, Sun& Shuang-yan, Yang& Feng-lei, Du& Xiao-long, Cheng& Li, Qing-lin& Meng-yuan, Chen…[et al.]. 2018. Radiotherapy for Adult Medulloblastoma: Evaluation of Helical Tomotherapy, Volumetric Intensity Modulated Arc Therapy, and Three-Dimensional Conformal Radiotherapy and the Results of Helical Tomotherapy Therapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129526
Modern Language Association (MLA)
Zong-wen, Sun…[et al.]. Radiotherapy for Adult Medulloblastoma: Evaluation of Helical Tomotherapy, Volumetric Intensity Modulated Arc Therapy, and Three-Dimensional Conformal Radiotherapy and the Results of Helical Tomotherapy Therapy. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129526
American Medical Association (AMA)
Zong-wen, Sun& Shuang-yan, Yang& Feng-lei, Du& Xiao-long, Cheng& Li, Qing-lin& Meng-yuan, Chen…[et al.]. Radiotherapy for Adult Medulloblastoma: Evaluation of Helical Tomotherapy, Volumetric Intensity Modulated Arc Therapy, and Three-Dimensional Conformal Radiotherapy and the Results of Helical Tomotherapy Therapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129526