Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?
Joint Authors
Kang, Honglei
Liu, Huiyong
Wang, Jia
Song, Chao
Zhang, Zheng
Guan, Hanfeng
Fang, Zhong
Li, Feng
Kim, Brett
Lu, Chanyi
Sun, Yunlong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Numerous physiological processes of mammals, including bone metabolism, are regulated by the circadian clock system, which consists of a central regulator, the suprachiasmatic nucleus (SCN), and the peripheral oscillators of the BMAL1/CLOCK-PERs/CRYs system.
Various bone turnover markers and bone metabolism-regulating hormones such as melatonin and parathyroid hormone (PTH) display diurnal rhythmicity.
According to previous research, disruption of the circadian clock due to shift work, sleep restriction, or clock gene knockout is associated with osteoporosis or other abnormal bone metabolism, showing the importance of the circadian clock system for maintaining homeostasis of bone metabolism.
Moreover, common causes of osteoporosis, including postmenopausal status and aging, are associated with changes in the circadian clock.
In our previous research, we found that agonism of the circadian regulators REV-ERBs inhibits osteoclast differentiation and ameliorates ovariectomy-induced bone loss in mice, suggesting that clock genes may be promising intervention targets for abnormal bone metabolism.
Moreover, osteoporosis interventions at different time points can provide varying degrees of bone protection, showing the importance of accounting for circadian rhythms for optimal curative effects in clinical treatment of osteoporosis.
In this review, we summarize current knowledge about circadian rhythms and bone metabolism.
American Psychological Association (APA)
Song, Chao& Wang, Jia& Kim, Brett& Lu, Chanyi& Zhang, Zheng& Liu, Huiyong…[et al.]. 2018. Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129528
Modern Language Association (MLA)
Song, Chao…[et al.]. Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129528
American Medical Association (AMA)
Song, Chao& Wang, Jia& Kim, Brett& Lu, Chanyi& Zhang, Zheng& Liu, Huiyong…[et al.]. Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129528