Bone Response to Titanium Implants Coated with Double- or Single-Stranded DNA
Joint Authors
Miyamoto, Nagahiro
Yamachika, Rina
Sakurai, Toshitsugu
Hosoya, Noriyasu
Hayakawa, Tohru
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We aimed to evaluate in vivo bone response and in vitro apatite formation to titanium (Ti) implants, coated with double-stranded DNA (DNA-d) or single-stranded DNA (DNA-s), and to compare the influence in different structure of DNA, double strand and single strand on bone response and apatite formation.
The bone responses to multilayered DNA-d/protamine or DNA-s/protamine coating implants were evaluated after implantation into the extracted sockets of rat maxillary molars.
Apatite formation on either coating surface after immersion in simulated body fluid (SBF) was evaluated using the quartz crystal microbalance (QCM) method.
DNA-d/protamine and DNA-s/protamine coatings produced more roughened and hydrophilic surfaces than untreated Ti.
Animal experiments showed that higher bone-to-implant ratios were achieved 3 and 6 weeks after implantation using DNA-d/protamine and DNA-s/protamine coatings compared with Ti.
QCM measurements revealed that each coating contributed to significant earlier apatite formation in SBF.
We conclude that both DNA-d/protamine and DNA-s/protamine coatings enhanced early bone formation.
We suggest that a DNA-multilayer coating is useful for the surface modification of a Ti implant.
American Psychological Association (APA)
Miyamoto, Nagahiro& Yamachika, Rina& Sakurai, Toshitsugu& Hayakawa, Tohru& Hosoya, Noriyasu. 2018. Bone Response to Titanium Implants Coated with Double- or Single-Stranded DNA. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129588
Modern Language Association (MLA)
Miyamoto, Nagahiro…[et al.]. Bone Response to Titanium Implants Coated with Double- or Single-Stranded DNA. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129588
American Medical Association (AMA)
Miyamoto, Nagahiro& Yamachika, Rina& Sakurai, Toshitsugu& Hayakawa, Tohru& Hosoya, Noriyasu. Bone Response to Titanium Implants Coated with Double- or Single-Stranded DNA. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129588