Barriers and Advances in Kidney Preservation
Joint Authors
Hauet, T.
Allain, Géraldine
Badet, Lionel
Thuillier, Raphael
Kerforne, Thomas
Steichen, Clara
Hannaert, Patrick
Bon, D.
Barrou, B.
Salamé, E.
Roumy, J.
Jayle, C.
Giraud, S.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Despite the fact that a significant fraction of kidney graft dysfunctions observed after transplantation is due to ischemia-reperfusion injuries, there is still no clear consensus regarding optimal kidney preservation strategy.
This stems directly from the fact that as of yet, the mechanisms underlying ischemia-reperfusion injury are poorly defined, and the role of each preservation parameter is not clearly outlined.
In the meantime, as donor demography changes, organ quality is decreasing which directly increases the rate of poor outcome.
This situation has an impact on clinical guidelines and impedes their possible harmonization in the transplant community, which has to move towards changing organ preservation paradigms: new concepts must emerge and the definition of a new range of adapted preservation method is of paramount importance.
This review presents existing barriers in transplantation (e.g., temperature adjustment and adequate protocol, interest for oxygen addition during preservation, and clear procedure for organ perfusion during machine preservation), discusses the development of novel strategies to overcome them, and exposes the importance of identifying reliable biomarkers to monitor graft quality and predict short and long-term outcomes.
Finally, perspectives in therapeutic strategies will also be presented, such as those based on stem cells and their derivatives and innovative models on which they would need to be properly tested.
American Psychological Association (APA)
Steichen, Clara& Giraud, S.& Bon, D.& Barrou, B.& Badet, Lionel& Salamé, E.…[et al.]. 2018. Barriers and Advances in Kidney Preservation. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129591
Modern Language Association (MLA)
Steichen, Clara…[et al.]. Barriers and Advances in Kidney Preservation. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1129591
American Medical Association (AMA)
Steichen, Clara& Giraud, S.& Bon, D.& Barrou, B.& Badet, Lionel& Salamé, E.…[et al.]. Barriers and Advances in Kidney Preservation. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129591