Prognostic Characteristics of MACC1 Expression in Epithelial Ovarian Cancer
Joint Authors
Jeong, Hoiseon
Jung, Jiyoon
Oh, Hwa Eun
Choi, Jung-Woo
Lee, Eung Seok
Kim, Young-Sik
Lee, Ju-Han
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer.
However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established.
Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database.
Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1.51 (95% confidence interval (CI): 1.21 – 1.88), P = 0.00025) and progression-free survival (HR = 1.53 (95% CI: 1.24 – 1.89), P = 5.8e-05) in EOC patients.
We also found that the expression of MACC1 mRNA in EOC was 2.5 times higher than that in normal surface ovarian epithelium, which was statistically significant (P = 2.86e-7).
Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual EOC patients.
American Psychological Association (APA)
Jeong, Hoiseon& Jung, Jiyoon& Oh, Hwa Eun& Choi, Jung-Woo& Lee, Eung Seok& Kim, Young-Sik…[et al.]. 2018. Prognostic Characteristics of MACC1 Expression in Epithelial Ovarian Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1129593
Modern Language Association (MLA)
Jeong, Hoiseon…[et al.]. Prognostic Characteristics of MACC1 Expression in Epithelial Ovarian Cancer. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1129593
American Medical Association (AMA)
Jeong, Hoiseon& Jung, Jiyoon& Oh, Hwa Eun& Choi, Jung-Woo& Lee, Eung Seok& Kim, Young-Sik…[et al.]. Prognostic Characteristics of MACC1 Expression in Epithelial Ovarian Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1129593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129593