Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold
Joint Authors
Mariani, Erminia
Gabusi, Elena
Paolella, Francesca
Gambari, Laura
Filardo, Giuseppe
Manferdini, Cristina
Lisignoli, Gina
Kon, Elizaveta
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Knee osteochondritis dissecans (OCD) is a focal disease of the joint characterized by modifications of bone and cartilage tissues.
Biomimetic osteochondral scaffolds are used to restore these tissues.
The aim of this prognostic prospective cohort study was to evaluate serum biomarkers of cartilage (fragments or propeptide of type II collagen: CTXII, C2C, and CPII) and bone (tartrate-resistant acid phosphatase (TRAP) 5b and osteocalcin (OC)) turnover during follow-up of patients treated with an osteochondral scaffold, to identify which were related to healing outcome and clinical score.
We found that cartilage (CPII) and bone (OC) synthetic biomarkers were significantly increased during the first-year follow-up, while the respective degradative markers (CTXII, C2C, and TRAP5b) were not modulated.
Only CTXII/CPII and C2C/CPII cartilage ratios were significantly modulated, evidencing a higher remodeling of cartilage compared to bone tissue.
Cartilage and bone single biomarkers or ratios at one-year follow-up showed values close to or similar to those of healthy subjects.
International Knee Documentation Committee (IKDC) score significantly increased from T0 to T2, while the Tegner score did not.
Taking into consideration an IKDC score > 70 as clinical success, we found that all OCD cases with both CPII (> 300 pg/ml) and C2C/CPII (<0.35) presented IKDC scores of clinical success.
OCD patients treated with an osteochondral scaffold showed an improvement at one-year follow-up, evidenced by both clinical and serum cartilage biomarkers.
These data confirmed that cartilage and bone remodeling took place and showed that systemic biomarkers represent a sensitive tool for monitoring OCD patients during the follow-up.
American Psychological Association (APA)
Gabusi, Elena& Paolella, Francesca& Manferdini, Cristina& Gambari, Laura& Kon, Elizaveta& Filardo, Giuseppe…[et al.]. 2018. Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129643
Modern Language Association (MLA)
Gabusi, Elena…[et al.]. Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129643
American Medical Association (AMA)
Gabusi, Elena& Paolella, Francesca& Manferdini, Cristina& Gambari, Laura& Kon, Elizaveta& Filardo, Giuseppe…[et al.]. Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129643