Real-World Results of Aflibercept versus Ranibizumab for the Treatment of Exudative AMD Using a Fixed Regimen
Joint Authors
Murta, Joaquim
Providência, Joana
Rodrigues, Tiago M.
Oliveira, Mariana
Bernardes, João
Marques, João Pedro
Silva, Rufino
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Intravitreal injections of antivascular endothelial growth factors have been considered a milestone in the treatment of neovascular age-related macular degeneration (nAMD).
However, the increasing incidence of AMD and the burden of visits and injections overcharge both the patient and the healthcare systems.
Real-world solutions depend on treatment protocols aimed at optimizing the number of clinical visits while guaranteeing good functional outcomes.
We performed a retrospective analysis of 72 eyes from 63 naïve patients diagnosed with nAMD that underwent a fixed intravitreal protocol consisting of bimonthly injections after a three-month loading dose, with either Aflibercept or Ranibizumab (no predefined criteria for treatment selection).
Best corrected visual acuity (BCVA) and optical coherence tomography were analyzed at baseline and during follow-up clinical visits (months 3, 6, 12, and 18).
From the included participants, 42 followed a fixed regimen with Aflibercept and 30 with Ranibizumab.
At the 12-month visit, there was not a statistically significant difference in the mean change of BCVA between the two groups (p=0.121); however, the mean difference in the central retinal thickness was significantly superior in the Aflibercept group (-142.2 versus -51.5, p=0.011).
The described fixed regimen seems to be efficient in the treatment of nAMD in a clinical practice setting.
American Psychological Association (APA)
Providência, Joana& Rodrigues, Tiago M.& Oliveira, Mariana& Bernardes, João& Marques, João Pedro& Murta, Joaquim…[et al.]. 2018. Real-World Results of Aflibercept versus Ranibizumab for the Treatment of Exudative AMD Using a Fixed Regimen. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1129648
Modern Language Association (MLA)
Providência, Joana…[et al.]. Real-World Results of Aflibercept versus Ranibizumab for the Treatment of Exudative AMD Using a Fixed Regimen. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1129648
American Medical Association (AMA)
Providência, Joana& Rodrigues, Tiago M.& Oliveira, Mariana& Bernardes, João& Marques, João Pedro& Murta, Joaquim…[et al.]. Real-World Results of Aflibercept versus Ranibizumab for the Treatment of Exudative AMD Using a Fixed Regimen. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1129648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129648