Benefits of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A Systematic Review and Meta-Analysis
Joint Authors
Tang, Yongquan
Liu, Zhihong
Zou, Zijun
Liang, Jiayu
Lu, Yiping
Zhu, Yuchun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The adjuvant use of mitotane on adrenocortical carcinoma (ACC) has always been in controversy.
We aimed to assess the prognostic benefits of adjuvant mitotane after resection of ACC in patients without distant metastasis.
Methods.
The PubMed, WoS, Embase, and Cochrane Library databases were systematically searched.
Recurrence-free survival (RFS) and overall survival (OS) were adopted as measurements.
A meta-analysis was conducted based on hazard ratio (HR) with 95% confidence interval (CI).
A study was included only if the enrolled patients underwent resection of ACC without adjuvant chemotherapy except mitotane.
Results.
A total of 5 retrospective studies reporting on 1249 patients were included for this meta-analysis.
The meta-analysis showed that adjuvant mitotane was significantly associated with prolonged RFS (HR = 0.62; 95%CI, 0.42-0.94; P < 0.05) and prolonged OS (HR = 0.69; 95%CI, 0.55-0.88, P < 0.05).
Conclusion.
After comprehensive review, current evidence suggests that adjuvant mitotane significantly decreases the recurrence rate and mortality after resection of ACC in patients without distant metastasis, but these findings need further demonstration from prospective controlled trials.
American Psychological Association (APA)
Tang, Yongquan& Liu, Zhihong& Zou, Zijun& Liang, Jiayu& Lu, Yiping& Zhu, Yuchun. 2018. Benefits of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129697
Modern Language Association (MLA)
Tang, Yongquan…[et al.]. Benefits of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A Systematic Review and Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129697
American Medical Association (AMA)
Tang, Yongquan& Liu, Zhihong& Zou, Zijun& Liang, Jiayu& Lu, Yiping& Zhu, Yuchun. Benefits of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A Systematic Review and Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129697