Eryptosis: An Erythrocyte’s Suicidal Type of Cell Death
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Erythrocytes play an important role in oxygen and carbon dioxide transport.
Although erythrocytes possess no nucleus or mitochondria, they fulfil several metabolic activities namely, the Embden-Meyerhof pathway, as well as the hexose monophosphate shunt.
Metabolic processes within the erythrocyte contribute to the morphology/shape of the cell and important constituents are being kept in an active, reduced form.
Erythrocytes undergo a form of suicidal cell death called eryptosis.
Eryptosis results from a wide variety of contributors including hyperosmolarity, oxidative stress, and exposure to xenobiotics.
Eryptosis occurs before the erythrocyte has had a chance to be naturally removed from the circulation after its 120-day lifespan and is characterised by the presence of membrane blebbing, cell shrinkage, and phosphatidylserine exposure that correspond to nucleated cell apoptotic characteristics.
After eryptosis is triggered there is an increase in cytosolic calcium (Ca2+) ion levels.
This increase causes activation of Ca2+-sensitive potassium (K+) channels which leads to a decrease in intracellular potassium chloride (KCl) and shrinkage of the erythrocyte.
Ceramide, produced by sphingomyelinase from the cell membrane’s sphingomyelin, contributes to the occurrence of eryptosis.
Eryptosis ensures healthy erythrocyte quantity in circulation whereas excessive eryptosis may set an environment for the clinical presence of pathophysiological conditions including anaemia.
American Psychological Association (APA)
Repsold, Lisa& Joubert, Anna M. 2018. Eryptosis: An Erythrocyte’s Suicidal Type of Cell Death. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129714
Modern Language Association (MLA)
Repsold, Lisa& Joubert, Anna M. Eryptosis: An Erythrocyte’s Suicidal Type of Cell Death. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129714
American Medical Association (AMA)
Repsold, Lisa& Joubert, Anna M. Eryptosis: An Erythrocyte’s Suicidal Type of Cell Death. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129714