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Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature
Joint Authors
Niparuck, Pimjai
Kanoksil, Wasana
Wacharapornin, Pathawut
Chantrathammachart, Pichika
Boongird, Sarinya
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Pure red cell aplasia (PRCA) is less common blood disorder; the causes and the treatments of PRCA are varied.
Methods.
We conducted a retrospective study during January 2010–December 2017, to explore the etiologies and to evaluate the response and treatment burden in adult patients with PRCA.
Results.
Of 32 PRCA patients, median age was 57 years (18–90 years).
Median hemoglobin level and reticulocyte count at the time of diagnosis were 5.6 g/dL (3.3–7.3 g/dL) and 0.3% (0.1–0.7%), respectively.
Median time to hematologic recovery was 12 weeks (3–72 weeks), and median number of red blood cell transfusion (RBC) was 20 units (4–100 units).
Causes of PRCA were erythropoiesis-stimulating agent (ESA) (47%), parvovirus B19 infection (19%), thymoma (13%), zidovudine (6%), primary autoimmune PRCA (6%), Kaposi’s sarcoma (3%), systemic lupus erythematosus (3%), and ABO-mismatched stem cell transplantation (3%).
Only 9 out of 24 treated patients achieved hematologic response within 8 weeks of treatment.
Intravenous immunoglobulin therapy provided 100% response rate in patients with parvovirus B19-associated PRCA and primary autoimmune PRCA.
Low response rate was found in patients receiving immunosuppressants and chemotherapy for the treatment of ESA and thymoma-associated PRCA, respectively.
Conclusions.
Treatment outcome of PRCA depended upon the causes and the types of treatment, and the burden of RBC transfusion was very high in patients with ESA and thymoma-associated PRCA.
American Psychological Association (APA)
Niparuck, Pimjai& Kanoksil, Wasana& Wacharapornin, Pathawut& Chantrathammachart, Pichika& Boongird, Sarinya. 2020. Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature. Anemia،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1129728
Modern Language Association (MLA)
Niparuck, Pimjai…[et al.]. Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature. Anemia No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1129728
American Medical Association (AMA)
Niparuck, Pimjai& Kanoksil, Wasana& Wacharapornin, Pathawut& Chantrathammachart, Pichika& Boongird, Sarinya. Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature. Anemia. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1129728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129728