Peripheral Blood Lymphocyte-to-Monocyte Ratio as a Useful Prognostic Factor in Newly Diagnosed Multiple Myeloma
Joint Authors
Chen, Wen-ming
Zhang, Yue
Chen, Xiao-Lei
Zhou, He-Bing
Tian, Ying
Zhu, Wan-Qiu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The survival of individuals with tumors may be predicted by the peripheral blood lymphocyte-to-monocyte ratio (LMR) upon diagnosis in recent studies.
For patients with multiple myeloma (MM) in the era of novel agents, the prognostic significance of LMR remains unclear.
In this study, the prognostic impact of LMR is evaluated by 285 patients with MM who are treated with proteasome inhibitor and/or immunomodulatory drug.
LMR is a proven predictor of survival using the receiver operating characteristic curve, with 4.2 as the cutoff point.
Patients with LMR ≤ 4.2 at diagnosis had poorer overall survival (OS) and progression-free survival (PFS) than those with LMR > 4.2.
In addition, multivariate analysis showed that LMR less than 4.2 is an independent predictor for the OS (hazard ratio [HR]: 1.703; 95% confidence interval [CI]: 1.020–2.842; P = 0.042) and PFS (HR: 1.831; 95% CI: 1.098–3.053; P = 0.021).
According to the test, the LMR at diagnosis, which functions as a simple index reflecting host systemic immunity, can predict clinical outcomes in patients with MM who are treated with new agents.
American Psychological Association (APA)
Tian, Ying& Zhang, Yue& Zhu, Wan-Qiu& Chen, Xiao-Lei& Zhou, He-Bing& Chen, Wen-ming. 2018. Peripheral Blood Lymphocyte-to-Monocyte Ratio as a Useful Prognostic Factor in Newly Diagnosed Multiple Myeloma. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129750
Modern Language Association (MLA)
Tian, Ying…[et al.]. Peripheral Blood Lymphocyte-to-Monocyte Ratio as a Useful Prognostic Factor in Newly Diagnosed Multiple Myeloma. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129750
American Medical Association (AMA)
Tian, Ying& Zhang, Yue& Zhu, Wan-Qiu& Chen, Xiao-Lei& Zhou, He-Bing& Chen, Wen-ming. Peripheral Blood Lymphocyte-to-Monocyte Ratio as a Useful Prognostic Factor in Newly Diagnosed Multiple Myeloma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129750