Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in NcNga Mice
Joint Authors
Chang, Sung Eun
Choi, Sun Young
Lee, You Jin
Kim, Ji Min
Kang, Hyun Ji
Cho, Sang Hyun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a defective immunologic barrier, which is aggravated by Staphylococcus aureus (S.
aureus).
Epidermal growth factor (EGF) suppresses inflammation and EGF receptor inhibitors increased S.
aureus colonization.
Thus, we investigated the potential roles of EGF in AD, which is often aggravated by S.
aureus.
We determined how EGF affects the expression of inflammatory cytokines and antimicrobial peptides (AMPs) in human epidermal keratinocytes (HEKs) treated with heat-inactivated S.
aureus (HKSA) in vitro and 2,4-dinitrochlorobenzene-induced AD-like skin lesions in Nc/Nga mice.
HKSA increased IL-6 and NFκB expression; EGF treatment had the opposite effect.
EGF increased human β defensin-2 expression in HEKs and murine β defensin-3 in mice.
In mice, both EGF and pimecrolimus groups showed less erythema with significantly reduced inflammation and decreased expression of thymic stromal lymphopoietin.
EGF relieved S.
aureus-induced inflammation and AD-like skin lesions in Nc/Nga mice.
Therefore, EGF could be a potential topical treatment for AD.
American Psychological Association (APA)
Choi, Sun Young& Lee, You Jin& Kim, Ji Min& Kang, Hyun Ji& Cho, Sang Hyun& Chang, Sung Eun. 2018. Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in NcNga Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129754
Modern Language Association (MLA)
Choi, Sun Young…[et al.]. Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in NcNga Mice. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129754
American Medical Association (AMA)
Choi, Sun Young& Lee, You Jin& Kim, Ji Min& Kang, Hyun Ji& Cho, Sang Hyun& Chang, Sung Eun. Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in NcNga Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129754