Systematic Review and Meta-Analysis of the Utility of Circular RNAs as Biomarkers of Hepatocellular Carcinoma
Joint Authors
Hao, Qingqin
Han, Yadi
Xia, Wei
Wang, Qinghui
Qian, Huizhong
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Emerging studies have reported circRNAs were dysregulated in HCC.
However, the clinical value of these circRNAs remains to be clarified.
Herein, we aimed to comprehensively explore their association with the diagnosis, prognosis, and clinicopathological characteristics of HCC.
PubMed, EMBASE, Web of Science, and Cochrane Library databases were comprehensively searched for eligible studies up to October 30, 2018.
The diagnostic effect was evaluated by the pooled sensitivity, specificity, and other indexes.
The pooled hazard ratio (HR) for overall survival (OS) and recurrence free survival (RFS) was calculated to assess the prognostic value.
Ten studies on diagnosis, 12 on prognosis, and 23 on clinicopathology were identified from the databases.
A total of 11 upregulated and 11 downregulated circRNAs showed an association with clinicopathological features of HCC.
For the diagnosis analyses, the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) of circRNAs for HCC were 0.74 (95%CI: 0.65-0.82) and 0.76 (95%CI: 0.70-0.81), 3.1 (95%CI: 2.5-3.8), 0.34 (95%CI: 0.25-0.47), and 9 (95%CI: 6-14), respectively.
The area under SROC curve (AUC) was 0.81 (95% CI: 0.78–0.84), indicating moderate diagnostic accuracy.
In stratified analyses, the diagnostic performance of circRNAs varied based on the source of control and specimen type.
For the prognosis analyses, increased expression of upregulated circRNAs was associated with worse OS (HR: 3.67, 95%: 2.07-6.48), while high expression of downregulated circRNAs was associated with better OS (HR: 0.38, 95%: 0.30-0.48).
In conclusion, this study reveals that circRNAs may serve as promising diagnostic and prognostic biomarkers for HCC.
However, further investigations are still required to explore the clinical value of circRNAs.
American Psychological Association (APA)
Hao, Qingqin& Han, Yadi& Xia, Wei& Wang, Qinghui& Qian, Huizhong. 2019. Systematic Review and Meta-Analysis of the Utility of Circular RNAs as Biomarkers of Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1129775
Modern Language Association (MLA)
Hao, Qingqin…[et al.]. Systematic Review and Meta-Analysis of the Utility of Circular RNAs as Biomarkers of Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1129775
American Medical Association (AMA)
Hao, Qingqin& Han, Yadi& Xia, Wei& Wang, Qinghui& Qian, Huizhong. Systematic Review and Meta-Analysis of the Utility of Circular RNAs as Biomarkers of Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1129775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129775