Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries
Joint Authors
Wang, Hui-shan
Ge, Xian-xiu
Li, Quan-peng
Nie, Jun-jie
Miao, Lin
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Prothrombin time (PT) can predict survival in several types of malignancies.
This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA).
Methods.
We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in our hospital from December 2008 to August 2017.
The relationship between PT and survival times was analyzed through univariate and multivariate analyses (Cox proportional hazards model).
Kaplan–Meier curves and log-rank test were used to assess the effects of PT on overall survival (OS) and tumor recurrence-free survival (RFS).
Results.
Increased PT level was an effective predictor for OS (P = 0.021; hazard ratio (HR), 1.799) and RFS (P = 0.016; HR, 1.871) in CCA patients, independent of age, tumor differentiation, and TNM stage.
In the low PT level group (PT < 12.3 s), patients showed a higher mean OS (23.03 m vs.
14.38 m, P = 0.0250) and RFS (17.78 m vs.
8.30 m, P = 0.0511) than those with high PT levels (PT ≥ 12.3 s).
A highly significant association was observed between high PT level and shortened OS (P = 0.0373) and worse RFS (P = 0.0151).
Conclusion.
Preoperative increase in PT can serve as a simple but effective predictor of poor survival in CCA patients who undergo curative surgeries.
American Psychological Association (APA)
Wang, Hui-shan& Ge, Xian-xiu& Li, Quan-peng& Nie, Jun-jie& Miao, Lin. 2019. Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1129821
Modern Language Association (MLA)
Wang, Hui-shan…[et al.]. Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1129821
American Medical Association (AMA)
Wang, Hui-shan& Ge, Xian-xiu& Li, Quan-peng& Nie, Jun-jie& Miao, Lin. Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1129821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129821