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Antibody-Mediated Osseous Regeneration for Bone Tissue Engineering in Canine Segmental Defects
Joint Authors
Zadeh, Homayoun H.
Mashhadiabbas, Fatemeh
Khojasteh, A.
Hosseinpour, S.
Dehghan, M. M.
Rezai Rad, M.
Farzad Mohajeri, S.
Ansari, Sahar
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Among many applications of therapeutic monoclonal antibodies (mAbs), a unique approach for regenerative medicine has entailed antibody-mediated osseous regeneration (AMOR).
In an effort to identify a clinically relevant model of craniofacial defect, the present study investigated the efficacy of mAb specific for bone morphogenetic protein- (BMP-) 2 to repair canine segmental mandibular continuity defect model.
Accordingly, a 15 mm unilateral segmental defect was created in mandible and fixated with a titanium plate.
Anorganic bovine bone mineral with 10% collagen (ABBM-C) was functionalized with 25 μg/mL of either chimeric anti-BMP-2 mAb or isotype-matched mAb (negative control).
Recombinant human (rh) BMP-2 served as positive control.
Morphometric analyses were performed on computed tomography (CT) and histologic images.
Bone densities within healed defect sites at 12 weeks after surgery were 1360.81 ± 10.52 Hounsfield Unit (HU), 1044.27 ± 141.16 HU, and 839.45 ± 179.41 HU, in sites with implanted anti-BMP-2 mAb, rhBMP-2, and isotype mAb groups, respectively.
Osteoid bone formation in anti-BMP-2 mAb (42.99% ± 8.67) and rhBMP-2 (48.97% ± 2.96) groups was not significantly different but was higher (p<0.05) than in sites with isotype control mAb (26.8% ± 5.35).
In view of the long-term objective of translational application of AMOR in humans, the results of the present study demonstrated the feasibility of AMOR in a large clinically relevant animal model.
American Psychological Association (APA)
Khojasteh, A.& Hosseinpour, S.& Dehghan, M. M.& Mashhadiabbas, Fatemeh& Rezai Rad, M.& Ansari, Sahar…[et al.]. 2018. Antibody-Mediated Osseous Regeneration for Bone Tissue Engineering in Canine Segmental Defects. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129827
Modern Language Association (MLA)
Khojasteh, A.…[et al.]. Antibody-Mediated Osseous Regeneration for Bone Tissue Engineering in Canine Segmental Defects. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129827
American Medical Association (AMA)
Khojasteh, A.& Hosseinpour, S.& Dehghan, M. M.& Mashhadiabbas, Fatemeh& Rezai Rad, M.& Ansari, Sahar…[et al.]. Antibody-Mediated Osseous Regeneration for Bone Tissue Engineering in Canine Segmental Defects. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129827