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The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases
Joint Authors
Khan, Nazir Ahmad
Han, Bo
Ali, Tariq
Gao, Jian
ur Rahman, Sadeeq
Ali, Ijaz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The β-lactams—a large class of diverse compounds—due to their excellent safety profile and broad antimicrobial spectrum are considered to be the most widely used therapeutic class of antibacterials prescribed in human and veterinary clinical practices.
This, unfortunately, has also given rise to a continuous increased resistance globally in health care settings as well as in the community due to their permanent selective force driving diversification of the resistance mechanism.
Resistance against β-lactams is increasing rapidly as novel β-lactamases, enzymes that degrade β-lactams, are being discovered each day such as recent emergence of extended spectrum β-lactamases (ESBL) that have the ability to inactivate most of the cephalosporins.
The complexity and diversity of ESBL are increasing so rapidly that more than 170 variants have thus far been described for only a single genotype, the blaCTX-M-encoding ESBL.
This review is to organize all the current updated literature describing genomic features, organization, and mechanism of resistance and mode of dissemination of all known ESBLs.
American Psychological Association (APA)
ur Rahman, Sadeeq& Ali, Tariq& Ali, Ijaz& Khan, Nazir Ahmad& Han, Bo& Gao, Jian. 2018. The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1129833
Modern Language Association (MLA)
ur Rahman, Sadeeq…[et al.]. The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1129833
American Medical Association (AMA)
ur Rahman, Sadeeq& Ali, Tariq& Ali, Ijaz& Khan, Nazir Ahmad& Han, Bo& Gao, Jian. The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1129833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129833