Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development
Joint Authors
Tang, Chih-Hsin
Yang, Wei-Hung
Wang, Shoou-Jyi
Chang, Yung-Sen
Su, Chen-Ming
Yang, Shun-Fa
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oral squamous cell carcinoma (OSCC) accounts for over 90% of malignant neoplasms of the mouth.
In Taiwan, OSCC is the fourth most common male cancer and the fourth leading cause of male cancer death.
Resistin (RETN) is an adipokine that is associated with obesity, inflammation, and various cancers.
Here, we examine the association between four single nucleotide polymorphisms (SNPs) of the RETN gene (rs3745367, rs7408174, rs1862513, and rs3219175) and OSCC susceptibility as well as clinical outcomes in 935 patients with OSCC and in 1200 cancer-free healthy controls.
We found that, in 1465 smokers, RETN polymorphisms carriers with the betel-nut chewing habit had a 6.708–10.882-fold greater risk of having OSCC compared to RETN wild-type carriers without the betel-nut chewing habit.
Patients with OSCC who had A/A homozygous of RETN rs3219175 polymorphism showed a high risk for an advanced tumor size (> T2), compared to those patients with G/G homozygotes.
In addition, A/T/G/G haplotype significantly increased the risks for OSCC by 1.376-fold.
This study is the first to examine the risk factors associated with RETN SNPs in OSCC progression and development in Taiwan.
American Psychological Association (APA)
Yang, Wei-Hung& Wang, Shoou-Jyi& Chang, Yung-Sen& Su, Chen-Ming& Yang, Shun-Fa& Tang, Chih-Hsin. 2018. Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129845
Modern Language Association (MLA)
Yang, Wei-Hung…[et al.]. Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129845
American Medical Association (AMA)
Yang, Wei-Hung& Wang, Shoou-Jyi& Chang, Yung-Sen& Su, Chen-Ming& Yang, Shun-Fa& Tang, Chih-Hsin. Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129845