Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients
Joint Authors
Merli, Manuela
Corsi, Alessandro
Ferri, Flaminia
Molinaro, Antonio
Poli, Edoardo
Parlati, Lucia
Lattanzi, Barbara
Mennini, Gianluca
Melandro, Fabio
Pugliese, Francesco
Maldarelli, Federica
Riminucci, Mara
Ginanni Corradini, Stefano
Lai, Quirino
Rossi, Massimo
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
No data are available on liver transplantation (LT) outcome and donor liver steatosis, classified as large droplet macrovesicular (Ld-MaS), small-droplet macrovesicular (Sd-MaS), and true microvesicular (MiS), taking into account the recipient Hepatitis C virus (HCV) status.
Aim.
We investigate the impact of allograft steatosis reclassified according to the Brunt classification on early graft function and survival after LT.
Methods.
We retrospectively reviewed 204 consecutive preischemia biopsies of grafts transplanted in our center during the period 2001-2011 according to recipient HCV status.
Results.
The median follow-up after LT was 7.5 years (range: 0.0-16.7).
In negative recipients (n=122), graft loss was independently associated with graft Sd-MaS, in multivariable Cox regression models comprehending only pre-/intraoperative variables (HR=1.03, 95%CI=1.01-1.05; P=0.003) and when including indexes of early postoperative graft function (HR=1.04, 95%CI=1.02-1.06; P=0.001).
Graft Sd-MaS>15% showed a risk for graft loss > 2.5-folds in both the models.
Graft Sd-MaS>15% was associated with reduced graft ATP content and, only in HCV- recipients, with higher early post-LT serum AST peaks.
Conclusions.
In HCV-negative recipients, allografts with >15% Sd-MaS have significantly reduced graft survival and show low ATP and higher AST peaks in the immediate posttransplant period.
Donors with >15% Sd-MaS have significantly higher BMI, longer ICU stays, and lower PaO2.
American Psychological Association (APA)
Ferri, Flaminia& Lai, Quirino& Molinaro, Antonio& Poli, Edoardo& Parlati, Lucia& Lattanzi, Barbara…[et al.]. 2019. Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1129877
Modern Language Association (MLA)
Ferri, Flaminia…[et al.]. Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1129877
American Medical Association (AMA)
Ferri, Flaminia& Lai, Quirino& Molinaro, Antonio& Poli, Edoardo& Parlati, Lucia& Lattanzi, Barbara…[et al.]. Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1129877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129877