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The Thomsen-Friedenreich Antigen-Specific Antibody Signatures in Patients with Breast Cancer
Joint Authors
Kurtenkov, Oleg
Klaamas, Kersti
Innos, Kaire
Sergejev, Boris
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alterations in the glycosylation of serum total immunoglobulins show these antibodies to have a diagnostic potential for cancer but the disease-related Abs to the tumor-associated antigens, including glycans, have still poorly been investigated in this respect.
We analysed serum samples from patients with breast carcinoma (n = 196) and controls (n = 64) for the level of Thomsen-Friedenreich (TF) antigen-specific antibody isotypes, their sialylation, interrelationships, and the avidity by using ELISA with the synthetic TF-polyacrylamide conjugate as an antigen and the sialic acid-specific Sambucus nigra agglutinin (SNA) and ammonium thiocyanate as a chaotrope.
An increased sialylation of IgG and IgM, but a lower SNA reactivity of IgA TF antibodies, and a higher level and avidity of the TF-specific IgA were found in cancer patients.
Other cancer-related signatures were the highly significant increase of the IgG/IgA ratio and the very low SNA/IgA index in cancer, including patients with an early stage of the disease.
These changes showed a good diagnostic potential with about 80% accuracy.
Thus, the level of naturally occurring anti-TF antigen antibodies, their sialylation profile, isotype distribution, and avidity displayed cancer-specific changes that could serve as novel noninvasive Ab-based biomarkers for early breast cancer.
American Psychological Association (APA)
Kurtenkov, Oleg& Innos, Kaire& Sergejev, Boris& Klaamas, Kersti. 2018. The Thomsen-Friedenreich Antigen-Specific Antibody Signatures in Patients with Breast Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129879
Modern Language Association (MLA)
Kurtenkov, Oleg…[et al.]. The Thomsen-Friedenreich Antigen-Specific Antibody Signatures in Patients with Breast Cancer. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129879
American Medical Association (AMA)
Kurtenkov, Oleg& Innos, Kaire& Sergejev, Boris& Klaamas, Kersti. The Thomsen-Friedenreich Antigen-Specific Antibody Signatures in Patients with Breast Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129879