Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
Joint Authors
Geng, Jingshu
Meng, Hong-xue
Miao, Su-sheng
Chen, Kexin
Li, Hui-ning
Yao, Guodong
Geng, Jiashi
Wang, Hongmei
Shi, Qing-tao
He, Jing
Mao, Xionghui
Tong, Fang-jia
Wei, Lan-Lan
Sun, Ji
Tan, Dongfeng
You, Qi
Li, Xiaomei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC).
Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC.
Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry.
Overexpression of p16 was observed in 81 (5.51%) of the 1470 cases, and HPV positive was present in 78 cases (5.31%) of the 1470 cases.
HPV positive and p16 overexpression have a good concordance.
However, we found that the etiological fraction of HPV in cancers of the OPSCCs was obviously lower in Northeast China than other cohorts previously reported.
Interestingly, nearly 89% of patients with p16 expression were smokers, and nearly 70% of patients with p16 expression had a history of alcohol.
Our study also demonstrates that p16 expression is significantly associated with early stage primary OPSCCs and the patients with p16 expression tend to show better survival following surgery and radiotherapy.
American Psychological Association (APA)
Meng, Hong-xue& Miao, Su-sheng& Chen, Kexin& Li, Hui-ning& Yao, Guodong& Geng, Jiashi…[et al.]. 2018. Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129881
Modern Language Association (MLA)
Meng, Hong-xue…[et al.]. Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129881
American Medical Association (AMA)
Meng, Hong-xue& Miao, Su-sheng& Chen, Kexin& Li, Hui-ning& Yao, Guodong& Geng, Jiashi…[et al.]. Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129881