Concomitant Sjögren’s Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis

Joint Authors

Ni, Ping
Men, Ruoting
Shen, Mengyi
Wang, Tingting
Huang, Chen
Fan, Xiaoli
Yang, Li

Source

Canadian Journal of Gastroenterology and Hepatology

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-06-02

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases
Medicine

Abstract EN

Aim.

Patients with primary biliary cholangitis (PBC) have at least 60% probability of having an autoimmune extrahepatic condition, with the most common being Sjögren’s syndrome (SS).

The impacts of SS on the response and outcomes in ursodeoxycholic acid (UDCA)-treated patients with PBC, however, remain unclear.

The aim of this study was to document the biochemical responses and clinical outcomes of UDCA-treated patients with concomitant SS and to compare the findings to those of patients with PBC alone.

Methods.

Data from consecutive patients with PBC who visited West China Hospital affiliated with Sichuan University between October 2013 and October 2017 were reviewed retrospectively.

Results.

The study populations consisted of 226 patients with PBC alone and 56 with PBC/SS.

The median ages, proportions of female patients, Fib-4 scores, and aspartate aminotransferase (AST)/platelet ratio index (APRI) at baseline in the two cohorts were similar.

At presentation, patients with PBC/SS had higher serum IgG levels and positive rates for serum antinuclear antibody (ANA) than patients with PBC alone (all P < 0.05).

There was no statistically significant difference between the rate of biochemical response to UDCA at 1 year in the PBC/SS and PBC alone groups.

The UK-PBC risk scores and GLOBE scores in UDCA-treated patients in the two cohorts were also similar.

During the follow-up period, the differences in the liver enzyme levels, Fib-4 scores, APRI, and incidence of liver-related adverse events were not significant.

Conclusions.

The results of this retrospective, single-center study suggest that the response and clinical outcomes of UDCA-treated patients with PBC are not adversely affected by concomitant SS.

American Psychological Association (APA)

Ni, Ping& Men, Ruoting& Shen, Mengyi& Wang, Tingting& Huang, Chen& Fan, Xiaoli…[et al.]. 2019. Concomitant Sjögren’s Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1129902

Modern Language Association (MLA)

Ni, Ping…[et al.]. Concomitant Sjögren’s Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1129902

American Medical Association (AMA)

Ni, Ping& Men, Ruoting& Shen, Mengyi& Wang, Tingting& Huang, Chen& Fan, Xiaoli…[et al.]. Concomitant Sjögren’s Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1129902

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1129902